R203, depends on the person, but it’s common for people to start out with mild symptoms and not feel too bad, then about a week in they feel much worse. That’s because it takes a while for the virus to multiply enough for the person to really get overwhelmed.
In Trump’s case, he’s probably got every comorbidity a person could have. Prediabetic (which is probably a lie, he’s probably diabetic and on meds for that), heart issues, probably had mini strokes the last few months, since he denied it, morbidly obese, high blood pressure probably managed by meds, high cholesterol, probably on blood thinners, which is actually good for COVID and might be keeping him alive. COVID patients are prone to blood clots. He’s probably got hardened arteries from all the junk he eats, so that makes blood clots worse.
They put him on Remdesivir very early, usually they wait until things are really bad. They give it to people with low oxygen. If the rumors are true, they hospitalized him because he was low oxygen. But the side affects for that are bad and the percentage of people with side effects is high, 10%+. It’s a 5-10 days dose. The longer you take it, the worse the side effects.
Remdesivir is supposed to slow down the virus from multiplying. It’s pretty likely Trump got a high viral load from exposing himself to sick people multiple times with no mask for long periods. There’s every reason to believe he’ll get a severe case. Remdesivir is not approved for the public yet, it’s still in the trial stage, and you don’t use the POTUS as a guinea pig normally.
Side effects include:
Randomized, double-blind, placebo-controlled trial in hospitalized adults with severe COVID-19 in China: Adverse events (e.g., constipation, hypoalbuminemia, hypokalemia, anemia, thrombocytopenia, increased total bilirubin concentrations) reported in 66 or 64% of patients who received remdesivir or placebo, respectively. Serious adverse events reported in 18 or 26%, respectively, and drug discontinued because of adverse events in 12 or 5%, respectively.
Phase 3, adaptive, randomized, placebo-controlled trial in hospitalized adults with mild/moderate or severe COVID-19 (NCT04280705; ACTT-1): Serious adverse events (e.g., cardiac events, respiratory distress or failure, acute kidney injury, hypotension) reported in 21% in remdesivir group and 27% in placebo group; grade 3 or 4 adverse events occurred in 29% in remdesivir group and 33% in placebo group. Most common nonserious grade 3 or greater adverse events in remdesivir group were anemia or decreased hemoglobin concentrations (8%); acute kidney injury, decreased eGFR or Clcr, or increased Scr (7%); pyrexia (5%); hyperglycemia or increased blood glucose concentrations (4%); and increased ALT and/or AST concentrations (4%); these were reported in 3–9% of patients in placebo group.
Phase 3, randomized, open-label trial in hospitalized adults with severe COVID-19 (NCT04292899; GS-US-540-5773; SIMPLE-Severe): Adverse events reported in 70 or 74% of patients who received a 5- or 10-day remdesivir regimen, respectively; serious adverse events (e.g., respiratory distress or failure, septic shock) reported in 21 or 35%, respectively, and grade 3 or greater adverse events reported in 30 or 43%, respectively. Drug discontinued because of adverse events in 4% of patients in 5-day group and 10% of patients in 10-day group. All-cause mortality at day 28 was 10 or 13% in the 5- or 10-day group, respectively. Most common adverse events overall were nausea (10 or 9%), acute respiratory failure (6 or 11%), increased ALT concentrations (6 or 8%), and constipation (7% in both groups),
They’ve been giving it to very sick people only because of severe, dangerous side effects. Diabetics are prone to kidney damage anyway, Trump could end up in dialysis after this. They know that. It’s a last ditch effort to save him, as it was for the other patients. Normally, this drug would never be approved due to severe side effects.