New anti-obesity drugs already outperform Ozempic

Will fat characters now cease to exist in film and television?

By more than 80 percent, I assume they mean about 98 per cent. If I see a story about someone’s dramatic weight loss, I always hope it’s due to Ozempic. Otherwise, it’s too depressing to think of how the hard-won weight loss will be reversed in no time.

Fat whores rejoice!

Keeping the weight off implies continued use, is that right?

I would assume.

I wouldnm try this new one. The side effects of ozempic are concering.

LET US TAKE THEM ALL!!!!!!

R4, I think these drugs are similar to statin drugs or hypertension drugs or insulin in that the patient will be on them long-term.

I'm not sure what to make of it. I think I'd be open to the competitor that's not a semaglutide like Ozempic Terzepatide. That one seems promising. Has a different approach to Ozempic.

Ya read it here first

Will the pen fit in my snack purse?

Aren’t the Chrissy Metz jokes kinda old now.

You don't have to laugh, R12. Hell, you don't even need to waste your precious minutes responding. It'll be okay, Sweetheart.

I would love to lose fifty pounds and be the weight I was in college again. I do exercise, I go running three times a week, but as I near 50 it doesn’t seem to be making much of a dent. I’d take a safe drug to shed it off in split second. Being overweight sucks.

I need to lose 30 pounds. But I can't take these drugs because all of them screw up your GI tract and mess with your liver and kidneys. I already have problems like that and I'm not going to make it worse. Metformin, which is popular really fucked me up. my doctor had to take me off it.

Speaking of Chrissy Metz, has she used these meds yet? That could be a real game changer for her.

Lizzo broke down and used them (despite her vehemently denying she did). I don't see why Chrissy Metz doesn't.

I'm starting week 6 on semaglutide and I've lost 18 lbs. Prior to starting it, I had lost 6 on my own and I've got 25 lbs to go before my goal weight.

So far I'm happy with it and have no side effects, and I'm definitely prone to GI issues.

[quote] Keeping the weight off implies continued use, is that right?

Yes, just like the natural, healthy way of diet and exercise requires maintaining healthy responsible eating habits. When someone is a recovering, gluttonous pig, it requires lifelong maintenance.

You know what outperforms ozempic?

They won't be losing a quarter of their skin, sadly.

[quote]You know what outperforms ozempic?

Mounjaro

R18, you just haven’t met the right girl yet. Keep praying and God will fix you.

The side effects on these drugs are nasty, and some people lose very little weight. They need to come up with better options that are more effective and have few side effects if they expect people to stay on these forever.

We don't miss her. Towards the end she had a terrible problem with flatulence. It was awful.

Only the poor will be fat; like only the poor are old and wrinkled.

OTOH - keep empty bottles or vials or whatever delivery they use. These are going through Trump's FDA; it's like they are being approved in Burundi.

I’ve been on tirzepatide for two months, and I have lost 24 pounds.

The only side effect I have had is occasional nausea. Previously , I would tend to snack throughout the day, and I am just not interested in doing it-I feel satisfied.

My energy is up, I am walking more, and my clothes are getting so loose I’m going to need to go shopping. I have had to learn to adjust the amount of groceries I would buy for a week, because I couldn’t consume that much food.

If I have to be on this for the rest of my life, so be it. The biggest problem with this medication is my insurance-they still won’t pay for it.

I just want “Magic” by Pilot to be a great oldie without all the baggage again.

So insurers gonna start covering these drugs for weight loss? Because they’re still mainly not.

I'm a Type 2 diabetic, Ozempic's intended audience. Something that's been forgotten. I've held it off since my early 50's with a good diet and daily exercise and eventually Metformin which kept me in "pre-diabetes" until it didn't. My internist had managed it for years but sent my to an endocrinologist who put me on Ozempic. I haven't lost any weight. I've had nausea once in the two years I've been on it.

It's a helluva lot easier to jab myself once a week (I'm up to 9 days between shots now which is fine with the endocrinologist because my A1C levels haven't been this consistently low for 20 years) than injecting insulin two or three times a day.

Which diabetics otherwise have to take for - wait for it - the rest of their lives.

A couple of months ago a friend went on Zepbound and he's lost some thirty pounds so far. So I signed up for it on that ro dot co site this week. It only took a couple of days for them to get me approved AND get my insurance onboard. According to them I'll only pay about $125 a month but that was before the insurance was factored in so I don't know yet what I'll actually be paying. The thing about going through that site is they initially set you up with their pharmacist in South Carolina, which is three time zones away from where I live. They wanted to charge me a $100 delivery fee on top of the monthly charge so I told them nope, I'll get it set up local. I'm just waiting on the ro dot co people to get that part set up.

A lot of body builders are on retatrutide, even though it hasn't yet been approved. Research seems to indicate that it's much more effective for weight-loss than either Wegovy or Zepbound.

Eli Lily hiked the price of Mounjaro by 170% in the UK after Trump's pressure.

Guess it's back to Wegovy!

I'm r17, and I see someone liked and commented on this thread, so I'll provide an update.

I lost 62 lbs altogether since the beginning of the year (Jan 4), and 6 on my own before starting to take compounded semaglutide. I've been off it for about at least a month now and I don't regret taking it, and would do it again. I have some leftover in case I start to creep up again, but for now, I actually lost 2 lbs more after I stopped and am maintaining. I'm lighter than I have been in over 20 years and I'm happy with the job it did.

R1 Those Weightwatchers and Jane Plan ads seem so desperate now.

R25 "Only the poor will be fat". Tell Erika-Jayne that!

Remember the old days when people used to exercise?

r35 what makes you think people who take Ozempic or Mounjaro or whatever don't exercise?

I certainly did while taking it.

someone I know is on one of these drugs, she was on it, lost some weight, then gained back some weight..she's been on off these drugs 3 times now. each time she stopped, she gained weight back...so dumb. she's in her 40s.

r37 She needs to stop stopping until she reaches her target weight. But yes, that's pretty common if you stop too early.

I was on compounded semaglutide and had side-effects from it, and I wasn’t losing much weight, so I stopped. I gained back what I had lost.

I’m on Zepbound now (the real brand name stuff) and it’s fucking amazing. Zero side-effects, and I’ve lost more weight in five weeks than I did after five months on semaglutide. I’m sure the newer drugs will be even better.

R39, does the real stuff still make it hard to make a poopie? That's the only side effect I didn't enjoy.

My boss (now retired) who was at least 40 lbs overweight took it for 3 months and never lost more than 5 lbs from it. I (r17 / r33) lost over 60 lbs, and another close friend lost 35 lbs (which is what she wanted to lose).

Turns out, he heard (months later) from his doctor that there has since been some info that there is a certain percentage of the population taking Zoloft (depression meds) don't lose ANY weight when they take semaglutide...something about the interactions of the meds on the receptors, in essence, BLOCK the effects of semaglutide.

I felt bad for him, because he also has heart disease and both his father and his brother died from heart attacks (in his brother's case, an early death in his 50s while cycling). He also exercises almost every day and carries all his excess weight in his belly.

He has decided (for the time being) not to try Mounjaro or any other different rx weight loss drugs because he saw others around him losing weight (not just me) and it really bummed him out that this - which could have been extremely beneficial for his health/disease - didn't help him. Perhaps in the future he will try something different. I really hope so; he's a great guy and friend and enjoying retirement with his wife. He deserves to be able to lose the weight and perhaps extend his life expectancy!

[quote][R39], does the real stuff still make it hard to make a poopie? That's the only side effect I didn't enjoy.

I don’t have that at all on Zepbound, no GI side effects.

r40 Isn't the more common side effect exactly the opposite, namely that it makes you violently shit yourself, at the most inopportune of times?

r17 chiming in again. Both my friend and I had the constipation effect with the compounded semaglutide, NOT diarrhea. I felt bad for her because she would go once a week(!) on the last day before her next dose. For me, it was more like 2 or 3 times a week.

That part isn't great, but it's a trade off, and honestly, if you drink more water (which many people - myself included - unwittingly decrease when on Ozempic) you can help with that. Also, try to eat more fibrous foods when you DO eat.

r15, where do you get your scientific information? Ozempic can actually improve kidney and liver function, especially for diabetics. Kidney function impairment is very rare -- but has been reported with those who already have kidney injury -- so beware. Meanwhile, liver impairment has simply not been an issue and is not on the list of warnings.

There's a lot of panic and rumor about these drugs.

R43 i was on a compound of the Ely lilly one with the extra stuff that was different than ozempic. Prior to going on the shot I normally would have a satisfying bowel movement every morning but once on that shot it stopped - I was plugged up and was told to take stool softeners because that was a common side effect. I could drink galore and not feel sick. My friend that was on the ozempic compound shot would feel nauseous after drinking 2 cocktails but could make 💩. I'm off it now and my 💩s are wonderful. But anyone doing this need to do weights otherwise you have hanging skin. I have a friend that did the same tirzepitide compound I did and swears that standing on a vibration plate for 15 minutes a day moved the fat away and helped her skin look tighter.