His premise is that because he, Will Wheaton, watched Eddie Murphy use the "f***ot" word repeatedly in his "Delirious" standup special, he became a homophobe, and then insulted a bunch of gay sports guys by using the f-word in front of them before he realized they were huge gaymos.
This is somehow exactly like Dave Chappelle saying in his standup special that the current trans activist movement has gone too far with its nonsense and mocking them, while also talking about his experience with an actual trans-identifying male. Because of that "The Closer" special, apparently people will grow up hating trans people, even though the special is in no way similar to the one he was mindraped by and doesn't denigrate trans people at all.
He also calls Dave Chapelle, who has railed at and mocked white people constantly in his specials, some sort of "KING OF CISHET WHITE DUDES" and then demands that EVERY COMEDIAN listed on the upcoming "Netflix is a Joke" comedy extravaganza should back out of it unless Dave Chappelle is removed from it.