Who are the best and worst replacements? Who is missing from this list?
Cheryl Ladd for Farrah Fawcett, Charlie's Angels
Woody Harrelson for Nicholas Colasanto, Cheers
Kirstie Alley for Shelley Long, Cheers
Javicia Leslie for Ruby Rose, Batwoman
Tiffani-Amber Thiessen for Shannen Doherty, Beverly Hills, 90210
Rose McGowan for Shannen Doherty, Charmed
Joe Mantegna for Mandy Patinkin, Criminal Minds
Byron Cherry and Christopher Mayer for John Schneider and Tom Wopat, The Dukes of Hazzard
Goran Visnjic for George Clooney, ER
Cloris Leachman for Charlotte Rae, The Facts of Life
Meaghan Rath and Beulah Koale for Grace Park and Daniel Dae Kim, Hawaii Five-0
Seann William Scott for Clayne Crawford, Lethal Weapon
Levy Tran for George Eads, MacGyver
Harry Morgan for McLean Stevenson, M*A*S*H
Jon Lovitz for Phil Hartman, NewsRadio
Jimmy Smits for David Caruso, NYPD Blue
James Spader for Steve Carell, The Office
Dax Shepard for Danny Masterson, The Ranch
Janina Gavankar for Nicole Beharie, Sleepy Hollow
Charlie Sheen for Michael J. Fox, Spin City
Josh Meyers for Topher Grace, That '70s Show
Jenilee Harrison and Priscilla Barnes for Suzanne Somers, Three's Company
Ashton Kutcher for Charlie Sheen, Two and a Half Men
Sandy Duncan for Valerie Harper, Valerie/Valerie's Family/The Hogan Family
Robert Patrick for David Duchovny, The X-Files