I almost think I might have caught it in Miami a few days before Christmas. For ~8 weeks every year (mid-November to January), I take Tamiflu & Ribavirin for prophylaxis, with Azithromycin to add if I get something that doesn't respond. Normally, it works brilliantly.
THIS past Christmas, it didn't. I developed a fever & cough on Christmas Eve, and started taking various combinations of ibuprofen, tylenol, and Aleve/naproxsyn with minimal success. Major fatigue, but no significant runny nose. Scratchy throat, but no sign of postnasal drip. Added azithromycin and prednisolone (the packs where you start with a high dose & quickly taper down over ~5 days), which if anything, made the coughing MORE frequent. It felt like pointless "dry" coughing that just erupted in fits out of the blue for no obvious reason. I added benzonatate for the cough, which (unsurprisingly) didn't seem do much (if anything).
It lasted about a week. The runny nose & post-nasal drip I expected never arrived... just constant fever that went between ~99F and 101F (I didn't lay off the tylenol/ibuprofen/Aleve until it finally went & stayed away for ~2 days). Mostly just tiredness, night sweats, and lots of pointless coughing.
Did anything I took make a difference? I have no idea. Tamiflu + Ribavirin obviously didn't prevent infection... but if what I had WAS C19, I honestly don't know whether I just had a mild case that was unaffected by all those meds, or whether whatever I had STAYED relatively mild just BECAUSE of them.
At the time, C19 didn't even have a proper name, and I was inclined to write it off as a weird cold (the one common respiratory infection Tamiflu + Ribavirin isn't known to do much for, though Ribavirin is still thought to weakly help with some colds).
I know Ribavirin was one of the originally-studied meds for C19 outside the US, but AFAIK it was never seriously studied IN the US (quite possibly because it's generally regarded as unsafe for pregnant women). My guess is that it didn't hurt, but if it did ANYTHING to help, it was only because I was taking it to begin with (200mg/day, increased to 2x/day on Christmas). Maybe it impaired the C19 enough to "flatten my own curve" so it was a steady annoyance rather than an explosive infection triggering a big cytokine backlash. Or maybe that would have happened regardless.
This is why I'm a big fan of open-label drug trials where you let millions of participants take as many or few meds as they like (no forced placebos), and just collect & log the relevant data (what & how much of any meds they took, daily PCR analysis, temperature readings, etc) then throw those millions of data points at a deep-learning algorithm to see whether it can discern a pattern. If you throw enough samples at it, you don't NEED to intentionally leave some participants blindly untreated, because they'll do it on their own (forgetting doses, stopping or never starting meds, etc). You just need a reliable way to monitor drug intake after the fact (like timestamped dried blood spots), because otherwise people will pretend to have been more compliant than they really were.