My partner and I are Angelenos. He is native born and I am a Boston transplant who moved here in 1991. From 2008-10 we lived in Portland and it's very much a mixed bag. While the natural setting is spectacular, the air is clean and the summers are glorious with Mediterranean temps and long days, the drawbacks are considerable. If you're used to the level of energy and cultural activity in Los Angeles, Portland will feel like a boring small town with lots of pretentious people who can't pull it off - in terms of literacy, fashion, design, etc.. A pot cloud hangs over the city, booze is everywhere and there's a sense of being in the middle of semi-depressing nowheresville - there's a reason why Portland's called "the place where young people go to retire." I couldn't understand the poor work ethnic and lack of ambition of many of the people there.
If you're looking for a vibrant economy, look elsewhere. Portland has many, many poor people, the standard of living is substantially lower than L.A. for professionals and the business environment is hostile - the locals seem to take pride in making it impossible for businesses to locate there in terms of taxes and environmental regulations. There's an overall sense that Portland has the "B" version of what you get in Los Angeles. As a Bostonian, it doesn't begin to compare to the amenities and cultural richness of that region, though at first glance some parts resemble it. Portland State University, OSU, Lewis and Clark and Reed College may be respectable but they're not Harvard, MIT, Boston University, etc..
We were called "fags" on the street twice (we're both fit, masculine bear types), which was off-putting and the liberal locals are rabid, radical leftists who can't tolerate any hint of a conservative opinion. A gay man literally spat on us once when we questioned the wisdom of massive illegal immigration coming to a poor state like Oregon. This same man was a college student in his 30's who supposedly wanted to teach art in Germany, yet had no clue about the major 20th century German artists I mentioned (Otto Dix, Christian Scad, George Grosz), nor had he even heard of New Objectivity. He was typical. Another person we knew was a lesbian in her mid-40's who was also a college student. She kept switching her major, as if she too had all the time in the world to get on with her life.
On the other hand, we met friends whom we still keep in touch with. People in Portland tend to love their homes and their gardens and the food is fresh and wonderful.
When we returned to L.A. we figuratively kissed the ground. Thank God we were able to sort of put Humpty Dumpty back together again after a few years of struggling. We now live in a very cute apartment in the Hollywood Dell neighborhood. And we still have the Irish Terrier we adopted there.
Moral of the story: when it comes to Portland, proceed with caution.