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I realized tonight one of my best friends has a mood disorder

For a year he has been behaving very erratically, and I wondered whether it was a midlife crisis. But tonight watching him swing from almost catatonically depressed to upbeat, then back to midway again, I realize there must be something chemically out of balance with him. He was behaving like other people I know who are bipolar when they're off they're meds. What should I do? He is in therapy but is not seeing a psychiatrist, nor is he on any meds. And could bi-polar disorder really manifest itself in his late 40s? Before this year he was fine (lightly depressed and in therapy, but not nearly so violently moody).

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