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The acting role that killed their careers

I know that here at DL St. Joan of Crawford is our patron saint. And we all know that Faye Dunaway's portrayal of Joan was an express ticket to career ruin for her. So with that template in mind, I'm curious if anyone else has good examples of a role, or a few roles, that led to career suicide? (Primarily film roles, but TV or theater could work, too.)

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